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Total 41234 results found since Jan 2013.
Vitamin D attenuates HMGB1-mediated neointimal hyperplasia after percutaneous coronary intervention in swine.
In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting. Yucatan microswine fed with a high-cholesterol diet were stratified to receive vitamin D-deficient (VD-DEF), vitamin D-sufficient (VD-SUF), and vitamin D-supplemented (VD-SUP) diet. After 6 months, PTCA (percutaneous transluminal balloon angioplasty) followed by bare metal stent implantation was performed in the lef...
Source: Molecular and Cellular Biochemistry - July 31, 2020 Category: Biochemistry Authors: Satish M, Gunasekar P, Asensio JA, Agrawal DK Tags: Mol Cell Biochem Source Type: research
Vitamin D Supplementation Reduces Intimal Hyperplasia and Restenosis following Coronary Intervention in Atherosclerotic Swine
In this study, we examined the effects of the deficiency and supplementation of vitamin D on coronary restenosis following coronary intervention in atherosclerotic Yucatan microswine. Twelve Yucatan microswine were fed vitamin D-deficient (n = 4) or -sufficient (n = 8) high cholesterol diet for 6-months followed by coronary intervention. Post-intervention, swine in the vitamin D-sufficient high cholesterol diet group received daily oral supplementation of either 1,000 IU (n = 4) or 3,000 IU (n = 4) vitamin D3. Six months later, optical coherence tomography (OCT) was performed to monitor the development of intimal hyperplas...
Source: PLoS One - June 5, 2016 Category: Biomedical Science Authors: Gaurav K. Gupta Source Type: research
Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine.
In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melan...
Source: Experimental and Molecular Pathology - November 13, 2013 Category: Pathology Authors: Trowbridge RM, Mitkov MV, Hunter WJ, Agrawal DK Tags: Exp Mol Pathol Source Type: research
Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine.
CONCLUSIONS: VD protects against atherosclerosis in hypercholesterolemic swine via controlling cholesterol efflux and macrophage polarization via increased CYP27A1 activation.
PMID: 26381871 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 17, 2015 Category: Cardiology Authors: Yin K, You Y, Swier V, Tang L, Radwan MM, Pandya AN, Agrawal DK Tags: Arterioscler Thromb Vasc Biol Source Type: research
Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine.
CONCLUSIONS: 1,25-dihydroxyvitamin D attenuates NF-κB activation by targeting KPNA4. Vitamin D deficiency accelerates CAD progression at least, in part, through enhanced chronic inflammation of EAT by upregulation of KPNA4, which enhances NF-κB activation. These novel findings provide mechanistic evidence that vitamin D supplementation could be beneficial for the prevention and treatment of CAD.
PMID: 27255724 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 1, 2016 Category: Cardiology Authors: Chen S, Swier VJ, Boosani CS, Radwan MM, Agrawal DK Tags: Arterioscler Thromb Vasc Biol Source Type: research
IJERPH, Vol. 19, Pages 1949: Effects of Sulfamethazine and Cupric Ion on Treatment of Anaerobically Digested Swine Wastewater with Growing Duckweed
Cheng
Duckweed (Spirodela polyrrhiza) has the potential to treat anaerobically digested swine wastewater (ADSW), but the effects of antibiotics and heavy metals in ADSW on the treatment performance and mechanism of Spirodela polyrrhiza are not clear. Herein, an experiment was conducted to investigate the effects of sulfamethazine (SMZ) and cupric ion on NH4+-N and total phosphorus (TP) removal from synthetic ADSW. The activity of superoxide dismutase (SOD) and the contents of photosynthetic pigments, vitamin E, and proteins in duckweed were also evaluated. Under the stress of SMZ, duckweed showed excellent removal effi...
Source: International Journal of Environmental Research and Public Health - February 10, 2022 Category: Environmental Health Authors: Yu Xiao Chunping Yang Jay J. Cheng Tags: Article Source Type: research
Towards improved phosphorus efficiency in monogastrics - Interplay of serum, minerals, bone and immune system after divergent dietary phosphorus supply in swine.
CONCLUSIONS: The modulated P-supplementation provoked considerable organismal plasticity. Genes found to be differentially expressed due to variable P-supply are involved in pathways relevant to P-utilization and are potential candidate genes for improved P-efficiency.
PMID: 26962023 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 9, 2016 Category: Physiology Authors: Oster M, Just F, Büsing K, Wolf P, Polley C, Vollmar B, Murani E, Ponsusksili S, Wimmers K Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
Maternal dietary vitamin D carry-over alters offspring growth, skeletal mineralisation and tissue mRNA expressions of genes related to vitamin D, calcium and phosphorus homoeostasis in swine.
Abstract
Maternal dietary vitamin D carry-over effects were assessed in young pigs to characterise skeletal abnormalities in a diet-induced model of kyphosis. Bone abnormalities were previously induced and bone mineral density (BMD) reduced in offspring from sows fed diets with inadequate vitamin D3. In a nested design, pigs from sows (n 23) fed diets with 0 (-D), 8·125 (+D) or 43·750 (++D) µg D3/kg from breeding through lactation were weaned and, within litter, fed nursery diets arranged as a 2×2 factorial design with 0 (-D) or 7·0 (+D) µg D3/kg, each with 95 % (95P) or 120 % (120P) of P requirements. Selec...
Source: The British Journal of Nutrition - August 1, 2016 Category: Nutrition Authors: Amundson LA, Hernandez LL, Laporta J, Crenshaw TD Tags: Br J Nutr Source Type: research
Role of Antioxidants in Horse Serum-mediated Vasculitis in Swine: Potential Relevance to Early Treatment in Mitigation of Coronary Arteritis in Kawasaki Disease
Horse serum-induced immune complex coronary vasculitis in swine is the first experimental model to mimic most of the pictures of Kawasaki disease. Immune complex mechanism has been implicated as one of the possible mechanisms in the pathogenesis of vasculitis in Kawasaki disease. Antioxidants have a significant role in the reduction of cardiovascular diseases in both human and animal studies. We tried giving vitamins A, E, and C to treat immune complex vasculitis, in the hope of mitigating coronary vasculitis in Kawasaki disease.
Source: Pediatrics and Neonatology - February 12, 2017 Category: Perinatology & Neonatology Authors: Saji Philip, Wen-Chuan Lee, Kotturathu Mammen Cherian, Mei-Hwan Wu, Hung-Chi Lue Tags: Original article Source Type: research
GSE201510 NGS-Muscle of swine supplemented with cholecalciferol and 25(OH)D
Contributors : Alicja Wierzbicka ; Maria Oczkowicz ; Tomasz Szmato łaSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofa domesticusAccording to RNA-seq results, application of vitamin D in the form of 25(OH)D in swine diet can be beneficial for myogenesis, energy production and muscle fibre formation by influencing TOR signalling pathway. However, the use of vitamin D in the form of 25(OH)D may reduce muscle respiratory capacity.
Source: GEO: Gene Expression Omnibus - January 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa domesticus Source Type: research
The Search for the Elusive Elixir of Life
By TOM EMERICK
Here’s the executive summary: Most disease and health spending is age-related. As we age we get infirmities ranging from dementia to cancer to vascular disease. Nothing can prevent aging. Period. For millennia mankind has been been on a futile search to prevent aging.
Search for the Elusive Elixir of Life
For 3500 or more years mankind has been searching for the mythological Elixir of Life, the fountain of youth, the philosophers stone, pool of nectar, etc, that will defeat aging and extend life, if not achieve immortality.
According to Wiki, “The elixir of life, also known as the elixir of immortality a...
Source: The Health Care Blog - February 4, 2016 Category: Consumer Health News Authors: Simon Nath Tags: THCB Tom Emerick Source Type: blogs
Evidence From Web-Based Dietary Search Patterns to the Role of B12 Deficiency in Non-Specific Chronic Pain: A Large-Scale Observational Study
Conclusions: Our findings show that Internet search patterns are a useful way of investigating health questions in large populations, and suggest that low B12 intake may be associated with a broader spectrum of neurological disorders than previously thought.
Source: Journal of Medical Internet Research - January 5, 2018 Category: General Medicine Authors: Eitan Giat Elad Yom-Tov Source Type: research
Nutritional Factors and Preservation of C-Peptide in Youth With Recently Diagnosed Type 1 Diabetes: SEARCH Nutrition Ancillary Study.
CONCLUSIONS Increased intake of branched-chain amino acids and long-chain omega-3 fatty acids may support preservation of β-cell function. This represents a new direction for research to improve prognosis for type 1 diabetes.
PMID: 23801797 [PubMed - in process]
Source: Diabetes Care - July 1, 2013 Category: Endocrinology Authors: Mayer-Davis EJ, Dabelea D, Crandell JL, Crume T, D'Agostino RB, Dolan L, King IB, Lawrence JM, Norris JM, Pihoker C, The N Tags: Diabetes Care Source Type: research
Serum biochemical, blood gas and antioxidant status in search and rescue dogs before and after simulated fieldwork
Publication date: Available online 6 July 2015 Source:The Veterinary Journal Author(s): J.W. Spoo , D.L. Zoran , R.L. Downey , K. Bischoff , J.J. Wakshlag The aim of the study was to assess the physiological and antioxidant status before and after a 4 h search and rescue field exercise, with handlers, under warm-weather conditions performing activities compared to a control group of similarly trained dogs at rest. Serum chemistry demonstrated a decrease in serum sodium (Na) and potassium (K) in both exercising and control groups, however only Na was decreased significantly (P < 0.05) after exercise and hematocrits...
Source: The Veterinary Journal - July 7, 2015 Category: Veterinary Research Source Type: research
Health economic analyses of psoriasis management: a systematic literature search
The objective was to identify health economic evaluations of psoriasis treatments that have been published to date. Of particular interest were the mostly used analysis and outcome parameters, the compared treatments, and the question, if available health economic studies may be used to perform a meta-analysis of qualitative findings. A systematic literature search using PubMed Medline, Ovid Medline, and Cochrane Library was performed for articles, published and available until mid of January 2016. Among the key words were the terms “psoriasis” and “cost-effectiveness”. The search resulted in 318 articles without d...
Source: Archives of Dermatological Research - July 18, 2016 Category: Dermatology Source Type: research
